Reduced retinoic acid synthesis accelerates prophase I and follicle activation
نویسندگان
چکیده
منابع مشابه
Thyroid hormone activation of retinoic acid synthesis in hypothalamic tanycytes
Thyroid hormone (TH) is essential for adult brain function and its actions include several key roles in the hypothalamus. Although TH controls gene expression via specific TH receptors of the nuclear receptor class, surprisingly few genes have been demonstrated to be directly regulated by TH in the hypothalamus, or the adult brain as a whole. This study explored the rapid induction by TH of ret...
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We have shown that four metabolites of all-trans-retinoic acid (ATRA) (4-oxo-, 4-OH-, 18-OH-, and 5,6-epoxy-RA) can induce maturation of NB4 promyelocytic leukemia cells (Idres, N., Benoit, G., Flexor, M. A., Lanotte, M., and Chabot, G. G. (2001) Cancer Res. 61, 700-705). To better understand the mechanism of action of ATRA metabolites and isomers, we assessed their binding to retinoic acid rec...
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ژورنال
عنوان ژورنال: Reproduction
سال: 2020
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-20-0221